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| Thesis Name： |
Studies on stereoselective synthesis of phenylglycine using D-glucopyranosylimine as chiral template |
| Usage： |
Studies on stereoselective synthesis of phenylglycine using D-glucopyranosylimine as chiral template |
| Keyword： |
N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)aldimine; Chiral auxiliary; Phenylglycine |
| Remarks： |
The N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)aldimine was used as chiral template for stereoselective synthesis of phenylglycine. The phenylglycine can be synthesized stereoselectively by the tin tetrachloride lewis acid induced addition of trimethylsilyl cyanide to N-(2,3,4,6-tetra-O-pivaloyl-D-glucopyranosyl)aldimine in the dichloromethane with the addition of a small quantity of triethylamine and then by acid-catalyzed hydrolysis. The synthetic method is efficient, economical and friendly to environment, giving the high yield and high ratio of diastereomers.
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| Original file： |
No File
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Promulgator Detail |
| Full name: |
hichem |
| Country: |
CN |
| City: |
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| Company Name: |
hichem |
| Homepage: |
http://www.teloon.com |
| E-mail: |
reply |
| Phone: |
86-411-82819585 |
| Fax: |
86-411-82819612 |
| Company Address: |
Renming Road, Dalian city, Lianning pro,china |
| Zip/Postal Code: |
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| Introduction: |
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