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| Research Domain： |
invention of new atom and group transfer-type reaction processes. |
| Keyword： |
Justin Du Bois |
| Research Production： |
Research in my group is based broadly in methods development and chemical synthesis. Our early efforts have concentrated on the invention of new atom and group transfer-type reaction processes. The application of such methods to problems in natural product synthesis and chemical biology offers unique challenges in reaction design, and serves as the underlying motivation for our research. As one of our overarching goals, we wish to devise molecular systems for selective C–H amination and hydroxylation that integrate concepts in catalysis with those in molecular recognition. Such ideas are inspired by Nature and the metalloenzymes that perform hydrocarbon oxidation reactions with exquisite fidelity. A general interest in problems in molecular recognition and molecular design has stimulated our more recent work towards understanding the structure and physiology of ion channels. Altogether, projects in the group are intended to afford students expertise in synthetic chemistry while exposing them to problems in chemical kinetics and catalysis, physical organic and coordination chemistry, and structure design. Currently, we have four principal areas of concentration that include: • The elucidation of new reaction processes for carbon-heteroatom (C–N and C–O) bond formation through selective, metal-catalyzed C–H and s-bond functionalization. • Mechanistic analysis of Rh-promoted C–H amination; coordination chemistry and catalyst design. • Multi-step, asymmetric syntheses of complex, heterocyclic amine-derived natural products which include the manzacidins, tetrodotoxin, saxitoxin, aconitine, welwitindolinone, and agelastatin. • The development of guanidine toxin mimetics that function as tools for mapping the tertiary structure of the ion permeation pathway in voltage-gated Na+ and Ca2+ ion channel proteins. |
| Remarks： |
Associate Professor (b. 1969)
Education: B.S., 1992, University of California at Berkeley; Ph.D., 1997, California Institute of Technology
Awards: NIH Postdoctoral Fellow, 1997-1999, Massachusetts Institute of Technology
Research Area:
Organic, Inorganic and Biological Chemistry
Phone: 650-724-4557
E-mail: jdubois@stanford.edu
Organization:University
Relationship: Faculty
Position: Assoc Professor
Department: Chemistry Operations
Fax:(650) 725-0259
Work Address:S G MUDD, Rm. #191
Stanford, California, 94305-5080 |
| Original file： |
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Promulgator Info |
| Full name: |
administrator |
| Country: |
CN |
| City: |
Dalian |
| Company Name: |
teloon Soft Strategy Co.,LTD |
| Homepage: |
http://m.hqsq.net |
| E-mail: |
reply |
| Phone: |
86-411-82811662 |
| Fax: |
86-411-82819667 |
| Company Address: |
26 Renmin Road ,Dalian China |
| Zip/Postal Code: |
116001 |
| Introduction: |
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