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Research Domain: Pharmacology
Keyword: James Ferrell
Research Production: Research Interests

Much of our research centers on the signal transduction pathways that trigger Xenopus oocyte maturation. This is an intrinsically important question--it sits at the heart of understanding fertility and reproduction--with a rich history of spinning off discoveries with broad implications for our understanding of the cell cycle (e.g. the discovery of M-phase promoting factor, MPF).

In addition, the signal transduction networks that trigger Xenopus oocyte maturation--the MAPK cascade and the Cdc2-cyclin B system--are of great importance in many biological contexts. We are studying how these networks function as systems. The oocyte provides in vitro and ex vivo experimental systems of unequaled power for carrying out quantitative biochemical studies, and we complement these experimental studies with computational approaches.
Remarks: Email: James.Ferrell@stanford.edu
Phone:(650) 725-0765
Profile: http://med.stanford.edu/profiles/James_Ferrell/ Academic  
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