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" The Robinson laboratory is interested in understanding the
fundamental interactions between molecules, both in isolation and in the
complex environment of the cell. We use our growing understanding to
design proteins with more robust or novel properties and to engineer
cellular systems for improved production or drug screening applications.
To this end, we are investigating the determinants of protein folding and
misfolding, on both an atomic and molecular level. We have developed
several novel approaches to inhibiting protein misfolding and aggregation.
Additionally, we are designing cellular systems for optimal expression of
membrane proteins, and antibodies.Our approach uses techniques in
molecular biology, genetic engineering, and biophysical chemistry to
identify and study macromolecules at both an atomic and cellular level.
Mechanistic modeling guides us in experimental design and analysis. We use
both prokaryotic, or bacterial, systems as well as eukaryotic systems,
such as yeast or mammalian cells. A major goal of this research is to
establish a set of cellular systems that could express any protein of
interest. The research in the laboratory has focus areas in protein
stability, expression, and aggregation for biotechnology and biomedical
applications. "
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